Institute for Biodiversity and Ecosystem Dynamics

IBED Seminar by Prof. Ivana Gudelj

18May2017 16:00 - 17:00

Lecture

Title: Microbial cooperation and virulence: when Hamiltonian medicine fails

 

Speaker

Dr. Ivana Gudelj, University of Exeter, UK

Abstract

Existing theory, empirical, clinical and field research all predict that reducing the virulence of individuals within a pathogen population will reduce the overall virulence, rendering disease less severe. Here, we show that this seemingly successful disease management strategy (sometimes termed Hamiltonian medicine) can fail with devastating consequences for infected hosts. We deploy cooperation theory and a novel synthetic system involving the rice blast fungus Magnaporthe oryzae. In vivo infections of rice demonstrate that M. oryzae virulence is enhanced, quite paradoxically, when a public good mutant is present in a population of high-virulence pathogens. We reason that during infection, the fungus engages in multiple cooperative acts to exploit host resources. We establish a multi-trait cooperation model which suggests that the observed failure of the virulence reduction strategy is caused by the interference between different social traits. Multi-trait cooperative interactions are widespread, so we caution against the indiscriminant application of anti-virulence therapy as a disease-management strategy.

 

Location: G2.10

Published by  IBED