Institute for Biodiversity and Ecosystem Dynamics

Photographer: Hans Westerhoff

prof. dr. H.V. (Hans) Westerhoff

  • Faculty of Science
    Swammerdam Institute for Life Sciences
  • Visiting address
    De Boelelaan 1108  
  • Postal address:
    Postbus  66
    1000 AB  Amsterdam
    T: 0205255150
    T: 0631998445




  • Wruck, W., Kashofer, K., Rehman, S., Daskalaki, A., Berg, D., Gralka, E., ... Adjaye, J. (2015). Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes. Scientific Data, 2, [150068]. DOI: 10.1038/sdata.2015.68  [details] 
  • Snoep, J. L., Green, K., Eicher, J., Palm, D. C., Penkler, G., du Toit, F., ... van Niekerk, D. D. (2015). Quantitative analysis of drug effects at the whole-body level: a case study for glucose metabolism in malaria patients. Biochemical Society Transactions, 43(6), 1157-1163. DOI: 10.1042/BST20150145  [details] 
  • Sellick, C. A., Croxford, A. S., Maqsood, A. R., Stephens, G. M., Westerhoff, H. V., Goodacre, R., & Dickson, A. J. (2015). Metabolite profiling of CHO cells: Molecular reflections of bioprocessing effectiveness. Biotechnology Journal, 10(9), 1434-1445. DOI: 10.1002/biot.201400664  [details] 
  • Westerhoff, H. V. (2015). Network-based pharmacology through systems biology. Drug Discovery Today. Technologies, 15, 15-16. DOI: 10.1016/j.ddtec.2015.05.001  [details] 
  • Lankelma, J., Kooi, B., Krab, K., Dorsman, J. C., Joenje, H., & Westerhoff, H. V. (2015). A reason for intermittent fasting to suppress the awakening of dormant breast tumors. Biosystems, 127, 1-6. DOI: 10.1016/j.biosystems.2014.11.001  [details] 
  • Westerhoff, H. V., Nakayama, S., Mondeel, T. D. G. A., & Barberis, M. (2015). Systems Pharmacology: An opinion on how to turn the impossible into grand challenges. Drug Discovery Today. Technologies, 15, 23-31. DOI: 10.1016/j.ddtec.2015.06.006  [details] 
  • Bastiaens, P., Birtwistle, M. R., Blüthgen, N., Bruggeman, F. J., Cho, K. H., Cosentino, C., ... Kholodenko, B. N. (2015). Silence on the relevant literature and errors in implementation. Nature Biotechnology, 33(4), 336-339. DOI: 10.1038/nbt.3185  [details] 
  • Rybakova, K. N., Bruggeman, F. J., Tomaszewska, A., Moné, M. J., Carlberg, C., & Westerhoff, H. V. (2015). Multiplex Eukaryotic Transcription (In)activation: Timing, Bursting and Cycling of a Ratchet Clock Mechanism. PLoS Computational Biology, 11(4), e1004236. DOI: 10.1371/journal.pcbi.1004236  [details] 
  • Rybakova, K. N., Tomaszewska, A., van Mourik, S., Blom, J., Westerhoff, H. V., Carlberg, C., & Bruggeman, F. J. (2015). Tracing the molecular basis of transcriptional dynamics in noisy data by using an experiment-based mathematical model. Nucleic Acids Research, 43(1), 153-161. DOI: 10.1093/nar/gku1272  [details] 



  • van Heeswijk, W. C., Westerhoff, H. V., & Boogerd, F. C. (2013). Nitrogen Assimilation in Escherichia coli: Putting Molecular Data into a Systems Perspective. Microbiology and Molecular Biology Reviews, 77(4), 628-695. DOI: 10.1128/MMBR.00025-13  [details] 
  • He, F., Fromion, V., & Westerhoff, H. V. (2013). (Im)Perfect robustness and adaptation of metabolic networks subject to metabolic and gene-expression regulation: marrying control engineering with metabolic control analysis. BMC Systems Biology, 7, [131]. DOI: 10.1186/1752-0509-7-131  [details] 
  • Feldman-Salit, A., Hering, S., Messiha, H. L., Veith, N., Cojocaru, V., Sieg, A., ... Fiedler, T. (2013). Regulation of the activity of lactate dehydrogenases from four lactic acid bacteria. The Journal of Biological Chemistry, 288(29), 21295-21306. DOI: 10.1074/jbc.M113.458265  [details] 
  • Geenen, S., Yates, J. W. T., Kenna, J. G., Bois, F. Y., Wilson, I. D., & Westerhoff, H. V. (2013). Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione-depletion biomarkers ophthalmic acid and 5-oxoproline in humans and rats. Integrative Biology, 5(6), 877-888. DOI: 10.1039/c3ib20245c  [details] 
  • Geenen, S., du Preez, F. B., Snoep, J. L., Foster, A. J., Sarda, S., Kenna, J. G., ... Westerhoff, H. V. (2013). Glutathione metabolism modeling: a mechanism for liver drug-robustness and a new biomarker strategy. Biochimica et Biophysica Acta G General Subjects, 1830(10), 4943-59. DOI: 10.1016/j.bbagen.2013.04.014  [details] 
  • Kolodkin, A., Sahin, N., Phillips, A., Hood, S. R., Bruggeman, F. J., Westerhoff, H. V., & Plant, N. (2013). Optimization of stress response through the nuclear receptor-mediated cortisol signalling network. Nature Communications, 4, 1792. DOI: 10.1038/ncomms2799  [details] 
  • Kolodkin, A., Simeonidis, E., & Westerhoff, H. V. (2013). Computing life: add logos to biology and bios to physics. Progress in Biophysics & Molecular Biology, 111(2-3), 69-74. DOI: 10.1016/j.pbiomolbio.2012.10.003  [details] 
  • Kouril, T., Esser, D., Kort, J., Westerhoff, H. V., Siebers, B., & Snoep, J. L. (2013). Intermediate instability at high temperature leads to low pathway efficiency for an in vitro reconstituted system of gluconeogenesis in Sulfolobus solfataricus. The FEBS Journal, 280(18), 4666-4680. DOI: 10.1111/febs.12438  [details] 
  • Mensonides, F. I., Bakker, B. M., Cremazy, F., Messiha, H. L., Mendes, P., Boogerd, F. C., & Westerhoff, H. V. (2013). A new regulatory principle for in vivo biochemistry: pleiotropic low affinity regulation by the adenine nucleotides--illustrated for the glycolytic enzymes of Saccharomyces cerevisiae. FEBS Letters, 587(17), 2860-2867. DOI: 10.1016/j.febslet.2013.07.013  [details] 
  • Quinton-Tulloch, M. J., Bruggeman, F. J., Snoep, J. L., & Westerhoff, H. V. (2013). Trade-off of dynamic fragility but not of robustness in metabolic pathways in silico. The FEBS Journal, 280(1), 160-173. DOI: 10.1111/febs.12057  [details] 
  • Smallbone, K., Messiha, H. L., Carroll, K. M., Winder, C. L., Malys, N., Dunn, W. B., ... Mendes, P. (2013). A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes. FEBS Letters, 587(17), 2832-2841. DOI: 10.1016/j.febslet.2013.06.043  [details] 
  • Thiele, I., Swainston, N., Fleming, R. M. T., Hoppe, A., Sahoo, S., Aurich, M. K., ... Palsson, B. Ø. (2013). A community-driven global reconstruction of human metabolism. Nature Biotechnology, 31(5), 419-25. DOI: 10.1038/nbt.2488  [details] 
  • Verma, M., Karimiani, E. G., Byers, R. J., Rehman, S., Westerhoff, H. V., & Day, P. J. (2013). 555 mediated BCR.ABL protein regulation in chronic myeloid leukaemia vis-a-vis therapeutic strategies. Integrative Biology, 5(3), 543-554. DOI: 10.1039/c3ib20230e  [details] 
  • Verma, M., Zakhartsev, M., Reuss, M., & Westerhoff, H. V. (2013). 'Domino' systems biology and the 'A' of ATP. Biochimica et Biophysica Acta - Bioenergetics, 1827(1), 19-29. DOI: 10.1016/j.bbabio.2012.09.014  [details] 


  • Adamczyk, M., & Westerhoff, H. V. (2012). Engineering of self-sustaining systems: substituting the yeast glucose transporter plus hexokinase for the Lactococcus lactis phosphotransferase system in a Lactococcus lactis network in silico. Biotechnology Journal, 7(7), 877-883. DOI: 10.1002/biot.201100314  [details] 
  • García-Contreras, R., Vos, P., Westerhoff, H. V., & Boogerd, F. C. (2012). Why in vivo may not equal in vitro - new effectors revealed by measurement of enzymatic activities under the same in vivo-like assay conditions. The FEBS Journal, 279(22), 4145-4159. DOI: 10.1111/febs.12007  [details] 
  • Geenen, S., Taylor, P. N., Snoep, J. L., Wilson, I. D., Kenna, J. G., & Westerhoff, H. V. (2012). Systems biology tools for toxicology. Archives of toxicology = Archiv für Toxikologie, 86(8), 1251-1271. DOI: 10.1007/s00204-012-0857-8  [details] 
  • Jozefczuk, J., Kashofer, K., Ummanni, R., Henjes, F., Rehman, S., Geenen, S., ... Adjaye, J. (2012). A systems biology approach to deciphering the etiology of steatosis employing patient-derived dermal fibroblasts and iPS cells. Frontiers in Physiology, 3, 339. DOI: 10.3389/fphys.2012.00339  [details] 
  • Kolodkin, A., Simeonidis, E., Balling, R., & Westerhoff, H. V. (2012). Understanding complexity in neurodegenerative diseases: in silico reconstruction of emergence. Frontiers in Physiology, 3, 291. DOI: 10.3389/fphys.2012.00291  [details] 
  • Rehman, S., Day, P. J. R., Bayat, A., & Westerhoff, H. V. (2012). Understanding Dupuytren's disease using systems biology: a move away from reductionism. Frontiers in Physiology, 3, 316. DOI: 10.3389/fphys.2012.00316  [details] 
  • van Eunen, K., Kiewiet, J. A. L., Westerhoff, H. V., & Bakker, B. M. (2012). Testing biochemistry revisited: how in vivo metabolism can be understood from in vitro enzyme kinetics. PLoS Computational Biology, 8(4), e1002483. DOI: 10.1371/journal.pcbi.1002483  [details] 


  • Geenen, S., du Preez, F. B., Reed, M., Nijhout, H. F., Kenna, J. G., Wilson, I. D., ... Snoep, J. L. (2011). A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolism. European Journal of Pharmaceutical Sciences, 46(4), 233-243. DOI: 10.1016/j.ejps.2011.08.017  [details] 
  • Sellick, C. A., Croxford, A. S., Maqsood, A. R., Stephens, G., Westerhoff, H. V., Goodacre, R., & Dickson, A. J. (2011). Metabolite profiling of recombinant CHO cells: designing tailored feeding regimes that enhance recombinant antibody production. Biotechnology and Bioengineering, 108(12), 3025-3031. DOI: 10.1002/bit.23269  [details] 


  • van Eunen, K., Bouwman, J., Daran-Lapujade, P., Postmus, J., Canelas, A. B., Mensonides, F. I. C., ... Bakker, B. M. (2010). Measuring enzyme activities under standardized in vivo-like conditions for systems biology. The FEBS Journal, 277(3), 749-760. DOI: 10.1111/j.1742-4658.2009.07524.x  [details] 


  • Härdin, H. M., Zagaris, A., Krab, K., & Westerhoff, H. V. (2009). Simplified yet highly accurate enzyme kinetics for cases of low substrate concentrations. The FEBS Journal, 276(19), 5491-5506. DOI: 10.1111/j.1742-4658.2009.07233.x  [details] 


This list of publications is extracted from the UvA-Current Research Information System. Questions? Ask the library  or the Pure staff  of your faculty / institute. Log in to Pure  to edit your publications. Log in to Personal Page Publication Selection tool  to manage the visibility of your publications on this list.
  • University of Manchester, SCEAS
  • Vrije Universiteit FALW

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