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Ms M.R. (Meggie) Hudspith

My research involves understanding how sponges, as complex associations of microbes and host cells, process one of their main dietary components, dissolved organic matter (DOM). Sponges represent the oldest living metazoans and are therefore exemplary model species in terms of unstanding early eukaryote-prokaryote relationships. My thesis aims to elucidate how nutrients are transferred between sponge cells and their associated microbes, and if this varies between different functional groups of sponges. I will be using complementary techniques to answer this question, including fatty acid analysis, cell separation techniques and cutting-edge NanoSIMS technology.
Faculty of Science
Institute for Biodiversity and Ecosystem Dynamics

Visiting address
  • Science Park 904
  • Room number:C4.208
Postal address
  • Postbus 94240
    1090 GE Amsterdam
Contact details
  • Profile

    I am interested in the relationship between sponges and their microbial communities. In particular, how each are involved in metabolising both organic and inorganic nutrients within the holobiont. My research primarily focuses on shallow water tropical sponges in Curacao.

    I use a variety of techniques to study host/microbial relationships, but my main focus is the use of NanoSIMS technology, which allows us to track the uptake and fate of labelled nutrients by the sponge at the subcellular level. This cutting-edge technique affords  novel insights into the dynamics of food processing within the sponge holobiont. By highlighting the role microbes play in sponge metabolism, we can better understand how sponges as a whole contribute to the cycling of limiting nutrients on coral reefs.

    Techniques used:

    • Nanoscale Secondary Ion Mass Spectroscopy (NanoSIMS)
    • Host-microbe cell separation
    • Fatty acid analysis
    • Stable isotope probing (13C and 15N)



  • Publications

    Hudspith, M., Reichelt-Brushett, A., Harrison, P.L. 2017. Factors affecting the toxicity of trace metals to fertilization success in broadcast spawning marine invertebrates: a review. Aquatic Toxicology 184:1-13

    Reichelt-Brushett, A., Hudspith, M. 2016. The effects of metals of emerging concern on the fertilization success of gametes of the tropical scleractinian coral Platygyra daedalea. Chemosphere 150:398-406.

    Hauton, C., Hudspith, M., Dean, L. 2015. Future prospects for prophylactic immune stimulation in crustacean aquaculture – the need for improved metadata to address immune system complexity. Developmental and Comparative Immunology 48:360-368.

  • Publications


    • Campana, S., Hudspith, M. R., Lankes, J. D., de Kluijver, A., Demey, C., Schoorl, J., Absalah, S., van der Meer, M. T. J., Müller, B., & de Goeij, J. M. (2021). Processing of Naturally Sourced Macroalgal- and Coral-Dissolved Organic Matter (DOM) by High and Low Microbial Abundance Encrusting Sponges. Frontiers in Marine Science, 8, [640583].
    • Hudspith, M., Rix, L., Achlatis, M., Bougoure, J., Guagliardo, P., Clode, P. L., Webster, N. S., Muyzer, G., Pernice, M., & de Goeij, J. M. (2021). Subcellular view of host–microbiome nutrient exchange in sponges: Insights into the ecological success of an early metazoan–microbe symbiosis. Microbiome, 9, [44]. [details]


    • de Goeij, J. (organiser), Hudspith, M. R. (organiser), Webster, N. S. (participant), Pernice, M. (participant), Rix, L. (participant) & Achlatis, M. (participant) (5-3-2018 - 9-3-2018). NanoSIMS and sponges, Perth. Workshop on NanoSIMS and sponges in Perth, Australia (organising a conference, workshop, ...).
    This list of publications is extracted from the UvA-Current Research Information System. Questions? Ask the library or the Pure staff of your faculty / institute. Log in to Pure to edit your publications. Log in to Personal Page Publication Selection tool to manage the visibility of your publications on this list.
  • Ancillary activities
    • No ancillary activities