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Institute for Biodiversity and Ecosystem Dynamics Institute for Biodiversity and Ecosystem Dynamics

Prof. dr. ir. A.G. (Agnes) Oomen

Faculty of Science
Institute for Biodiversity and Ecosystem Dynamics
Photographer: Kirsten van Santen
Visiting address
  • Science Park 904
Postal address
  • Postbus 94240
    1090 GE Amsterdam
Contact details
  • Profile

    Agnes is professor by special appointment of Chemicals and Planetary Health. She combines her work at the Institute of Biodiversity & Ecosystem Dynamics (IBED) with her position as senior scientific staff member at the National Institute of Public Health and the Environment (RIVM).

     

    Agnes has special interest in the fate/toxicokinetics, effects and risks of chemicals in the environment and for human health, improving chemical safety, sustainability and circularity and ensuring regulatory preparedness to anticipate future developments.

  • Research interest and background

    Agnes enjoys interdisciplinary research and to contribute from a scientific perspective to socially relevant topics. Working from oversight by taking into account the broader perspective, such as what is happening in policy and society in order to focus research and communication.

    After her study Molecular Sciences at the Wageningen University, Agnes did her PhD at the Institute for Risk Assessment Sciences (IRAS) at the Utrecht University (UU). She subsequently started as staff member at the RIVM.

    Agnes has been acting as senior scientist and project leader in projects on the presence, exposure and health risks of nanomaterials and advanced materials. For example on the health risk of TiO2 and SiO2 from food. Or PFAS in food contact materials. She also contributed to ad-hoc projects on potential health risks of PFOA and rubber infill. The last years, the focus has shifted to safety, sustainability and circularity, for example to the early identification of potential issues or to develop approaches and work forms to address this in the innovation stage.

    Agnes contributes to national projects as well as to European projects. She also is an expert for international organisations such as EFSA, ECHA and OECD.

  • Ancillary activities

    Agnes is senior scientific staff member at the Department Safe technological Innovations and Circular Economy (VIC) of the Center for Safety of Substances and Products (VSP) at the National Institute for Public Health and the Environment (RIVM).

    Agnes is member of the cross-cutting working group on nanomaterials of the European Food Safety Authority (EFSA). She is co-lead of the Organisation for Economic Co-operation and Development (OECD) Steering Group on advanced materials.

     

  • Publications

    2024

    • Di Battista, V., Sanchez-Lievanos, K. R., Jeliazkova, N., Murphy, F., Tsiliki, G., Zabeo, A., Gajewicz-Skretna, A., Mikołajczyk, A., Hristozov, D., Stone, V., Schmid, O., Hunt, N., Oomen, A. G., & Wohlleben, W. (2024). Similarity of multicomponent nanomaterials in a safer-by-design context: the case of core-shell quantum dots. Environmental Science: Nano, 11(3), 924-941 . https://doi.org/10.1039/d3en00338h [details]
    • Di Cristo, L., Keller, J. G., Leoncino, L., Marassi, V., Loosli, F., Ag Seleci, D., Tsiliki, G., Oomen, A. G., Stone, V., Wohlleben, W., & Sabella, S. (2024). Critical aspects in dissolution testing of nanomaterials in the oro-gastrointestinal tract: the relevance of juice composition for hazard identification and grouping. Nanoscale Advances, 6(3), 798-815. https://doi.org/10.1039/d3na00588g [details]
    • EFSA Panel on Food Additives and Flavourings (FAF) (2024). Re-evaluation of silicon dioxide (E 551) as a food additive in foods for infants below 16 weeks of age and follow-up of its re-evaluation as a food additive for uses in foods for all population groups. EFSA Journal, 22(10), Article e8880. https://doi.org/10.2903/j.efsa.2024.8880
    • Hof, M., de Baat, M. L., Noorda, J., Peijnenburg, W. J. G. M., van Wezel, A. P., & Oomen, A. G. (2024). Informing the public about chemical mixtures in the local environment: Currently applied indicators in the Netherlands and ways forward. Journal of Environmental Management, 368, Article 122108. https://doi.org/10.1016/j.jenvman.2024.122108 [details]
    • Hristozov, D., Badetti, E., Bigini, P., Brunelli, A., Dekkers, S., Diomede, L., Doak, S. H., Fransman, W., Gajewicz-Skretna, A., Giubilato, E., Gómez-Cuadrado, L., Grafström, R., Gutleb, A. C., Halappanavar, S., Hischier, R., Hunt, N., Katsumiti, A., Kermanizadeh, A., Marcomini, A., ... Zabeo, A. (2024). Next Generation Risk Assessment approaches for advanced nanomaterials: Current status and future perspectives. Nanoimpact, 35, Article 100523. https://doi.org/10.1016/j.impact.2024.100523 [details]
    • Puhlmann, N., Abbate, E., Kümmerer, K., Oomen, A. G., Ragas, A. M. J., & Moermond, C. (2024). Applicability of the European Commission's framework on safe and sustainable by design to the pharmaceutical sector. Sustainable Chemistry and Pharmacy, 42, Article 101845. https://doi.org/10.1016/j.scp.2024.101845 [details]

    2023

    • Monikh, F. A., Peijnenburg, W., Oomen, A. G., Valsami-Jones, E., Stone, V., Kortet, R., Akkanen, J., Zhang, P., Kekäläinen, J., Sevcu, A., & Kukkonen, J. V. K. (2023). “Advanced materials” and the challenges on the horizon for testing their (eco)toxicity and assessing their hazard. Environmental Science: Advances, 2(2), 162-170. https://doi.org/10.1039/D2VA00128D [details]
    • Murphy, F. A., Johnston, H. J., Dekkers, S., Bleeker, E. A. J., Oomen, A. G., Fernandes, T. F., Rasmussen, K., Jantunen, P., Rauscher, H., Hunt, N., di Cristo, L., Braakhuis, H. M., Haase, A., Hristozov, D., Wohlleben, W., Sabella, S., & Stone, V. (2023). How to formulate hypotheses and IATA to support grouping and read-across of nanoforms. Altex-Alternatives To Animal Experimentation, 40(1), 125–140. Advance online publication. https://doi.org/10.14573/altex.2203241 [details]
    • Schoonjans, R., Castenmiller, J., Chaudhry, Q., Cubadda, F., Daskaleros, T., Franz, R., Gott, D., Mast, J., Mortensen, A., Oomen, A. G., Rauscher, H., Weigel, S., Astuto, M. C., Cattaneo, I., Barthelemy, E., Rincon, A., & Tarazona, J. (2023). Regulatory safety assessment of nanoparticles for the food chain in Europe. Trends in Food Science & Technology, 134, 98-111. https://doi.org/10.1016/j.tifs.2023.01.017 [details]

    2022

    2021

    • Bischoff, N. S., de Kok, T. M., Sijm, D. T. H. M., van Breda, S. G., Briedé, J. J., Castenmiller, J. J. M., Opperhuizen, A., Chirino, Y. I., Dirven, H., Gott, D., Houdeau, E., Oomen, A. G., Poulsen, M., Rogler, G., & van Loveren, H. (2021). Possible adverse effects of food additive e171 (Titanium dioxide) related to particle specific human toxicity, including the immune system. International Journal of Molecular Sciences, 22(1), Article 207. https://doi.org/10.3390/ijms22010207
    • Braakhuis, H. M., Gosens, I., Heringa, M. B., Oomen, A. G., Vandebriel, R. J., Groenewold, M., & Cassee, F. R. (2021). Mechanism of Action of TiO2: Recommendations to Reduce Uncertainties Related to Carcinogenic Potential. Annual Review of Pharmacology and Toxicology, 61, 203-223. https://doi.org/10.1146/annurev-pharmtox-101419-100049
    • Braakhuis, H. M., Murphy, F., Ma-Hock, L., Dekkers, S., Keller, J., Oomen, A. G., & Stone, V. (2021). An Integrated Approach to Testing and Assessment to Support Grouping and Read-Across of Nanomaterials after Inhalation Exposure. Applied In Vitro Toxicology, 7(3), 112-128. https://doi.org/10.1089/aivt.2021.0009
    • Brand, W., van Kesteren, P. C. E., Peters, R. J. B., & Oomen, A. G. (2021). Issues currently complicating the risk assessment of synthetic amorphous silica (SAS) nanoparticles after oral exposure. Nanotoxicology, 15(7), 905-933. https://doi.org/10.1080/17435390.2021.1931724
    • Di Cristo, L., Oomen, A. G., Dekkers, S., Moore, C., Rocchia, W., Murphy, F., Johnston, H. J., Janer, G., Haase, A., Stone, V., & Sabella, S. (2021). Grouping hypotheses and an integrated approach to testing and assessment of nanomaterials following oral ingestion. Nanomaterials, 11(10), Article 2623. https://doi.org/10.3390/nano11102623
    • EFSA Panel on Food Additives and Flavourings (FAF) (2021). Safety assessment of titanium dioxide (E171) as a food additive. EFSA Journal, 19(5), Article e06585. https://doi.org/10.2903/j.efsa.2021.6585
    • EFSA Scientific Committee (2021). Guidance on risk assessment of nanomaterials to be applied in the food and feed chain: human and animal health. EFSA Journal, 19(8), Article e06768. https://doi.org/10.2903/j.efsa.2021.6768
    • Murphy, F., Dekkers, S., Braakhuis, H., Ma-Hock, L., Johnston, H., Janer, G., di Cristo, L., Sabella, S., Jacobsen, N. R., Oomen, A. G., Haase, A., Fernandes, T., & Stone, V. (2021). An integrated approach to testing and assessment of high aspect ratio nanomaterials and its application for grouping based on a common mesothelioma hazard. NANOIMPACT, 22, Article 100314. https://doi.org/10.1016/j.impact.2021.100314
    • Peijnenburg, W., Oomen, A. G., Soeteman-Hernández, L. G., Groenewold, M., Sips, A. J. A. M., Noorlander, C. W., Kettelarij, J. A. B., & Bleeker, E. A. J. (2021). Identification of emerging safety and sustainability issues of advanced materials: Proposal for a systematic approach. NANOIMPACT, 23, Article 100342. https://doi.org/10.1016/j.impact.2021.100342

    2020

    • Brand, W., Peters, R. J. B., Braakhuis, H. M., Maślankiewicz, L., & Oomen, A. G. (2020). Possible effects of titanium dioxide particles on human liver, intestinal tissue, spleen and kidney after oral exposure. Nanotoxicology, 14(7), 985-1007. https://doi.org/10.1080/17435390.2020.1778809
    • Peters, R. J. B., Oomen, A. G., van Bemmel, G., van Vliet, L., Undas, A. K., Munniks, S., Bleys, R. L. A. W., Tromp, P. C., Brand, W., & van der Lee, M. (2020). Silicon dioxide and titanium dioxide particles found in human tissues. Nanotoxicology, 14(3), 420-432. https://doi.org/10.1080/17435390.2020.1718232
    • Stone, V., Gottardo, S., Bleeker, E. A. J., Braakhuis, H., Dekkers, S., Fernandes, T., Haase, A., Hunt, N., Hristozov, D., Jantunen, P., Jeliazkova, N., Johnston, H., Lamon, L., Murphy, F., Rasmussen, K., Rauscher, H., Jiménez, A. S., Svendsen, C., Spurgeon, D., ... Oomen, A. G. (2020). A framework for grouping and read-across of nanomaterials- supporting innovation and risk assessment. Nano Today, 35, Article 100941. https://doi.org/10.1016/j.nantod.2020.100941

    2019

    • Giusti, A., Atluri, R., Tsekovska, R., Gajewicz, A., Apostolova, M. D., Battistelli, C. L., Bleeker, E. A. J., Bossa, C., Bouillard, J., Dusinska, M., Gómez-Fernández, P., Grafström, R., Gromelski, M., Handzhiyski, Y., Jacobsen, N. R., Jantunen, P., Jensen, K. A., Mech, A., Navas, J. M., ... Haase, A. (2019). Nanomaterial grouping: Existing approaches and future recommendations. NANOIMPACT, 16, Article 100182. https://doi.org/10.1016/j.impact.2019.100182
    • Mech, A., Rasmussen, K., Jantunen, P., Aicher, L., Alessandrelli, M., Bernauer, U., Bleeker, E. A. J., Bouillard, J., Di Prospero Fanghella, P., Draisci, R., Dusinska, M., Encheva, G., Flament, G., Haase, A., Handzhiyski, Y., Herzberg, F., Huwyler, J., Jacobsen, N. R., Jeliazkov, V., ... Apostolova, M. D. (2019). Insights into possibilities for grouping and read-across for nanomaterials in EU chemicals legislation. Nanotoxicology, 13(1), 119-141. https://doi.org/10.1080/17435390.2018.1513092
    • Soeteman-Hernandez, L. G., Apostolova, M. D., Bekker, C., Dekkers, S., Grafström, R. C., Groenewold, M., Handzhiyski, Y., Herbeck-Engel, P., Hoehener, K., Karagkiozaki, V., Kelly, S., Kraegeloh, A., Logothetidis, S., Micheletti, C., Nymark, P., Oomen, A., Oosterwijk, T., Rodríguez-LLopis, I., Sabella, S., ... Noorlander, C. W. (2019). Safe innovation approach: Towards an agile system for dealing with innovations. Materials Today Communications, 20, Article 100548. https://doi.org/10.1016/j.mtcomm.2019.100548

    2018

    • EFSA Scientific Committee (2018). Guidance on risk assessment of the application of nanoscience and nanotechnologies in the food and feed chain: Part 1, human and animal health. EFSA Journal, 16(7), Article e05327. https://doi.org/10.2903/j.efsa.2018.5327
    • Heringa, M. B., Peters, R. J. B., Bleys, R. L. A. W., van der Lee, M. K., Tromp, P. C., van Kesteren, P. C. E., van Eijkeren, J. C. H., Undas, A. K., Oomen, A. G., & Bouwmeester, H. (2018). Detection of titanium particles in human liver and spleen and possible health implications. Particle and Fibre Toxicology, 15(1), Article 15. https://doi.org/10.1186/s12989-018-0251-7
    • Oomen, A. G., Steinhäuser, K. G., Bleeker, E. A. J., van Broekhuizen, F., Sips, A., Dekkers, S., Wijnhoven, S. W. P., & Sayre, P. G. (2018). Risk assessment frameworks for nanomaterials: Scope, link to regulations, applicability, and outline for future directions in view of needed increase in efficiency. NANOIMPACT, 9, 1-13. https://doi.org/10.1016/j.impact.2017.09.001

    2017

    • De Jong, W. H., Oomen, A. G., Tran, L., Chaudhry, Q., & Lefebvre, D. E. (2017). Engineered Nanoparticles and Food: Exposure, Toxicokinetics, Hazards and Risks. In P. O'Brien, Q. Chaudhry, L. Castle, & R. Watkins (Eds.), Nanofluidics (2nd ed., pp. 200-227). (RSC Nanoscience and Nanotechnology; No. 42). Royal Society of Chemistry. https://doi.org/10.1039/9781782626879-00200
    • Scott-Fordsmand, J. J., Peijnenburg, W. J. G. M., Semenzin, E., Nowack, B., Hunt, N., Hristozov, D., Marcomini, A., Irfan, M. A., Jiménez, A. S., Landsiedel, R., Tran, L., Oomen, A. G., Bos, P. M. J., & Hund-Rinke, K. (2017). Environmental risk assessment strategy for nanomaterials. International Journal of Environmental Research and Public Health, 14(10), Article 1251. https://doi.org/10.3390/ijerph14101251

    2016

    • Braakhuis, H. M., Cassee, F. R., Fokkens, P. H. B., De La Fonteyne, L. J. J., Oomen, A. G., Krystek, P., De Jong, W. H., Van Loveren, H., & Park, M. V. D. Z. (2016). Identification of the appropriate dose metric for pulmonary inflammation of silver nanoparticles in an inhalation toxicity study. Nanotoxicology, 10(1), 63-73. https://doi.org/10.3109/17435390.2015.1012184
    • Braakhuis, H. M., Oomen, A. G., & Cassee, F. R. (2016). Grouping nanomaterials to predict their potential to induce pulmonary inflammation. Toxicology and Applied Pharmacology, 299, 3-7. https://doi.org/10.1016/j.taap.2015.11.009
    • Dekkers, S., Oomen, A. G., Bleeker, E. A. J., Vandebriel, R. J., Micheletti, C., Cabellos, J., Janer, G., Fuentes, N., Vázquez-Campos, S., Borges, T., Silva, M. J., Prina-Mello, A., Movia, D., Nesslany, F., Ribeiro, A. R., Leite, P. E., Groenewold, M., Cassee, F. R., Sips, A. J. A. M., ... Wijnhoven, S. W. P. (2016). Towards a nanospecific approach for risk assessment. Regulatory toxicology and pharmacology, 80, 46-59. https://doi.org/10.1016/j.yrtph.2016.05.037
    • Heringa, M. B., Geraets, L., van Eijkeren, J. C. H., Vandebriel, R. J., de Jong, W. H., & Oomen, A. G. (2016). Risk assessment of titanium dioxide nanoparticles via oral exposure, including toxicokinetic considerations. Nanotoxicology, 10(10), 1515-1525. Advance online publication. https://doi.org/10.1080/17435390.2016.1238113
    • Hristozov, D., Gottardo, S., Semenzin, E., Oomen, A., Bos, P., Peijnenburg, W., van Tongeren, M., Nowack, B., Hunt, N., Brunelli, A., Scott-Fordsmand, J. J., Tran, L., & Marcomini, A. (2016). Frameworks and tools for risk assessment of manufactured nanomaterials. Environment International, 95, 36-53. https://doi.org/10.1016/j.envint.2016.07.016
    • Rompelberg, C., Heringa, M. B., van Donkersgoed, G., Drijvers, J., Roos, A., Westenbrink, S., Peters, R., van Bemmel, G., Brand, W., & Oomen, A. G. (2016). Oral intake of added titanium dioxide and its nanofraction from food products, food supplements and toothpaste by the Dutch population. Nanotoxicology, 10(10), 1404-1414. https://doi.org/10.1080/17435390.2016.1222457

    2015

    • Bos, P. M. J., Gottardo, S., Scott-Fordsm, J. J., van Tongeren, M., Semenzin, E., Fernandes, T. F., Hristozov, D., Hund-Rinke, K., Hunt, N., Irfan, M. A., Landsiedel, R., Peijnenburg, W. J. G. M., Jiménez, A. S., van Kesteren, P. C. E., & Oomen, A. G. (2015). The MARINA risk assessment strategy: A flexible strategy for efficient information collection and risk assessment of nanomaterials. International Journal of Environmental Research and Public Health, 12(12), 15007-15021. https://doi.org/10.3390/ijerph121214961
    • Delmaar, C. J. E., Peijnenburg, W. J. G. M., Oomen, A. G., Chen, J., de Jong, W. H., Sips, A. J. A. M., Wang, Z., & Park, M. V. D. Z. (2015). A practical approach to determine dose metrics for nanomaterials. Environmental Toxicology and Chemistry, 34(5), 1015-1022. https://doi.org/10.1002/etc.2878
    • Farcal, L., Andón, F. T., Di Cristo, L., Rotoli, B. M., Bussolati, O., Bergamaschi, E., Mech, A., Hartmann, N. B., Rasmussen, K., Riego-Sintes, J., Ponti, J., Kinsner-Ovaskainen, A., Rossi, F., Oomen, A., Bos, P., Chen, R., Bai, R., Chen, C., Rocks, L., ... Fadeel, B. (2015). Comprehensive in vitro toxicity testing of a panel of representative oxide nanomaterials: First steps towards an intelligent testing strategy. PLoS ONE, 10(5), Article e0127174. https://doi.org/10.1371/journal.pone.0127174
    • Noorlander, C. W., Kooi, M. W., Oomen, A. G., Park, M. V. D. Z., Vandebriel, R. J., & Geertsma, R. E. (2015). Horizon scan of nanomedicinal products. Nanomedicine, 10(10), 1599-1608. https://doi.org/10.2217/nnm.15.21
    • Oomen, A. G., Bleeker, E. A. J., Bos, P. M. J., van Broekhuizen, F., Gottardo, S., Groenewold, M., Hristozov, D., Hund-Rinke, K., Irfan, M. A., Marcomini, A., Peijnenburg, W. J. G. M., Rasmussen, K., Sánchez Jiménez, A., Scott-Fordsmand, J. J., van Tongeren, M., Wiench, K., Wohlleben, W., & Landsiedel, R. (2015). Grouping and read-across approaches for risk assessment of nanomaterials. International Journal of Environmental Research and Public Health, 12(10), 13415-13434. https://doi.org/10.3390/ijerph121013415
    • Van Kesteren, P. C. E., Cubadda, F., Bouwmeester, H., Van Eijkeren, J. C. H., Dekkers, S., De Jong, W. H., & Oomen, A. G. (2015). Novel insights into the risk assessment of the nanomaterial synthetic amorphous silica, additive E551, in food. Nanotoxicology, 9(4), 442-452. https://doi.org/10.3109/17435390.2014.940408

    2014

    • Geraets, L., Oomen, A. G., Krystek, P., Jacobsen, N. R., Wallin, H., Laurentie, M., Verharen, H. W., Brandon, E. F. A., & de Jong, W. H. (2014). Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats. Particle and Fibre Toxicology, 11(1), Article 30. https://doi.org/10.1186/1743-8977-11-30
    • Oomen, A. G., Bos, P. M. J., Fernandes, T. F., Hund-Rinke, K., Boraschi, D., Byrne, H. J., Aschberger, K., Gottardo, S., Von Der Kammer, F., Kühnel, D., Hristozov, D., Marcomini, A., Migliore, L., Scott-Fordsmand, J., Wick, P., & Landsiedel, R. (2014). Concern-driven integrated approaches to nanomaterial testing and assessment-report of the NanoSafety Cluster Working Group 10. Nanotoxicology, 8(3), 334-348. https://doi.org/10.3109/17435390.2013.802387
    • Oomen, A., Bos, P., & Landsiedel, R. (2014). Concern-driven safety assessment of nanomaterials: An integrated approach using material properties, hazard, biokinetic, and exposure data and considerations on grouping and read-across. In Safety of Nanomaterials along Their Lifecycle: Release, Exposure, and Human Hazards (pp. 357-380). CRC Press. https://doi.org/10.1201/b17774
    • Peters, R. J. B., Van Bemmel, G., Herrera-Rivera, Z., Helsper, H. P. F. G., Marvin, H. J. P., Weigel, S., Tromp, P. C., Oomen, A. G., Rietveld, A. G., & Bouwmeester, H. (2014). Characterization of titanium dioxide nanoparticles in food products: Analytical methods to define nanoparticles. Journal of Agricultural and Food Chemistry, 62(27), 6285-6293. https://doi.org/10.1021/jf5011885

    2013

    • Dekkers, S., Bouwmeester, H., Bos, P. M. J., Peters, R. J. B., Rietveld, A. G., & Oomen, A. G. (2013). Knowledge gaps in risk assessment of nanosilica in food: Evaluation of the dissolution and toxicity of different forms of silica. Nanotoxicology, 7(4), 367-377. https://doi.org/10.3109/17435390.2012.662250

    2012

    • Brandon, E. F. A., Baars, A. J., Biesebeek, J. D. T., Oomen, A. G., Bakker, M. I., & De Heer, C. (2012). Risk assessment of patulin intake from apple containing products by young children. World Mycotoxin Journal, 5(4), 391-403. https://doi.org/10.3920/WMJ2012.1426
    • Geraets, L., Oomen, A. G., Schroeter, J. D., Coleman, V. A., & Cassee, F. R. (2012). Tissue distribution of inhaled micro- and nano-sized cerium oxide particles in rats: Results from a 28-day exposure study. Toxicological Sciences, 127(2), 463-473. https://doi.org/10.1093/toxsci/kfs113
    • Peters, R., Kramer, E., Oomen, A. G., Herrera Rivera, Z. E., Oegema, G., Tromp, P. C., Fokkink, R., Rietveld, A., Marvin, H. J. P., Weigel, S., Peijnenburg, A. A. C. M., & Bouwmeester, H. (2012). Presence of nano-sized silica during in vitro digestion of foods containing silica as a food additive. ACS Nano, 6(3), 2441-2451. https://doi.org/10.1021/nn204728k

    2011

    • Dekkers, S., Krystek, P., Peters, R. J. B., Lankveld, D. P. K., Bokkers, B. G. H., Van Hoeven-Arentzen, P. H., Bouwmeester, H., & Oomen, A. G. (2011). Presence and risks of nanosilica in food products. Nanotoxicology, 5(3), 393-405. https://doi.org/10.3109/17435390.2010.519836
    • Lankveld, D. P. K., Rayavarapu, R. G., Krystek, P., Oomen, A. G., Verharen, H. W., Van Leeuwen, T. G., De Jong, W. H., & Manohar, S. (2011). Blood clearance and tissue distribution of PEGylated and non-PEGylated gold nanorods after intravenous administration in rats. Nanomedicine, 6(2), 339-349. https://doi.org/10.2217/nnm.10.122
    • Wragg, J., Cave, M., Basta, N., Brandon, E., Casteel, S., Denys, S., Gron, C., Oomen, A., Reimer, K., Tack, K., & Van de Wiele, T. (2011). An inter-laboratory trial of the unified BARGE bioaccessibility method for arsenic, cadmium and lead in soil. Science of the Total Environment, 409(19), 4016-4030. https://doi.org/10.1016/j.scitotenv.2011.05.019

    2010

    • Lankveld, D. P. K., Oomen, A. G., Krystek, P., Neigh, A., Troost - de Jong, A., Noorlander, C. W., Van Eijkeren, J. C. H., Geertsma, R. E., & De Jong, W. H. (2010). The kinetics of the tissue distribution of silver nanoparticles of different sizes. Biomaterials, 31(32), 8350-8361. https://doi.org/10.1016/j.biomaterials.2010.07.045

    2009

    • Wijnhoven, S. W. P., Peijnenburg, W. J. G. M., Herberts, C. A., Hagens, W. I., Oomen, A. G., Heugens, E. H. W., Roszek, B., Bisschops, J., Gosens, I., Van De Meent, D., Dekkers, S., De Jong, W. H., Van Zijverden, M., Sips, A. J. A. M., & Geertsma, R. E. (2009). Nano-silver - A review of available data and knowledge gaps in human and environmental risk assessment. Nanotoxicology, 3(2), 109-138. https://doi.org/10.1080/17435390902725914

    2007

    • Grøn, C., Oomen, A., Weyand, E., & Wittsiepe, J. (2007). Bioaccessibility of PAH from Danish soils. Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering, 42(9), 1233-1239. https://doi.org/10.1080/10934520701435619
    • Hagens, W. I., Oomen, A. G., de Jong, W. H., Cassee, F. R., & Sips, A. J. A. M. (2007). What do we (need to) know about the kinetic properties of nanoparticles in the body? Regulatory toxicology and pharmacology, 49(3), 217-229. https://doi.org/10.1016/j.yrtph.2007.07.006
    • Hansen, J. B., Oomen, A. G., Edelgaard, I., & Grøn, C. (2007). Oral bioaccessibility and leaching: Tests for soil risk assessment. Engineering in Life Sciences, 7(2), 170-176. https://doi.org/10.1002/elsc.200620174
    • Ljung, K., Oomen, A., Duits, M., Selinus, O., & Berglund, M. (2007). Bioaccessibility of metals in urban playground soils. Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering, 42(9), 1241-1250. https://doi.org/10.1080/10934520701435684
    • Van De Wiele, T. R., Oomen, A. G., Wragg, J., Cave, M., Minekus, M., Hack, A., Cornelis, C., Rompelberg, C. J. M., De Zwart, L. L., Klinck, B., Van Wijnen, J., Verstraete, W., & Sips, A. J. A. M. (2007). Comparison of five in vitro digestion models to in vivo experimental results: Lead bioaccessibility in the human gastrointestinal tract. Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering, 42(9), 1203-1211. https://doi.org/10.1080/10934520701434919

    2006

    • Brandon, E. F. A., Oomen, A. G., Rompelberg, C. J. M., Versantvoort, C. H. M., Van Engelen, J. G. M., & Sips, A. J. A. M. (2006). Consumer product in vitro digestion model: Bioaccessibility of contaminants and its application in risk assessment. Regulatory toxicology and pharmacology, 44(2), 161-171. https://doi.org/10.1016/j.yrtph.2005.10.002

    2005

    • Versantvoort, C. H. M., Oomen, A. G., Van De Kamp, E., Rompelberg, C. J. M., & Sips, A. J. A. M. (2005). Applicability of an in vitro digestion model in assessing the bioaccessibility of mycotoxins from food. Food and chemical toxicology, 43(1), 31-40. https://doi.org/10.1016/j.fct.2004.08.007

    2004

    • Oomen, A. G., Rompelberg, C. J. M., Van De Kamp, E., Pereboom, D. P. K. H., De Zwart, L. L., & Sips, A. J. A. M. (2004). Effect of Bile Type on the Bioaccessibility of Soil Contaminants in an In Vitro Digestion Model. Archives of Environmental Contamination and Toxicology, 46(2), 183-188. https://doi.org/10.1007/s00244-003-2138-2

    2003

    • Oomen, A. G., Rompelberg, C. J. M., Bruil, M. A., Dobbe, C. J. G., Pereboom, D. P. K. H., & Sips, A. J. A. M. (2003). Development of an in vitro digestion model for estimating the bioaccessibility of soil contaminants. Archives of Environmental Contamination and Toxicology, 44(3), 281-287. https://doi.org/10.1007/s00244-002-1278-0
    • Oomen, A. G., Tolls, J., Sips, A. J. A. M., & Groten, J. P. (2003). In vitro intestinal lead uptake and transport in relation to speciation. Archives of Environmental Contamination and Toxicology, 44(1), 116-124. https://doi.org/10.1007/s00244-002-1226-z
    • Oomen, A. G., Tolls, J., Sips, A. J. A. M., & Van den Hoop, M. A. G. T. (2003). Lead speciation in artificial human digestive fluid. Archives of Environmental Contamination and Toxicology, 44(1), 107-115. https://doi.org/10.1007/s00244-002-1225-0

    2002

    • Oomen, A. G., Hack, A., Minekus, M., Zeijdner, E., Cornelis, C., Schoeters, G., Verstraete, W., Van De Wiele, T., Wragg, J., Rompelberg, C. J. M., Sips, A. J. A. M., & Van Wijnen, J. H. (2002). Comparison of five in vitro digestion models to study the bioaccessibility of soil contaminants. Environmental Science and Technology, 36(15), 3326-3334. https://doi.org/10.1021/es010204v

    2001

    • Oomen, A. G., Tolls, J., Kruidenier, M., Bosgra, S. S. D., Sips, A. J. A. M., & Groten, J. P. (2001). Availability of polychlorinated biphenyls (PCBs) and lindane for uptake by intestinal Caco-2 cells. Environmental Health Perspectives, 109(7), 731-737. https://doi.org/10.1289/ehp.01109731

    2000

    • Oomen, A. G., Mayer, P., & Tolls, J. (2000). Nonequilibrium solid-phase microextraction for determination of the freely dissolved concentration of hydrophobic organic compounds: Matrix effects and limitations. Analytical Chemistry, 72(13), 2802-2808. https://doi.org/10.1021/ac9914162
    • Oomen, A. G., Sips, A. J. A. M., Groten, J. P., Sijm, D. T. H. M., & Tolls, J. (2000). Mobilization of PCBs and lindane from soil during in vitro digestion and their distribution among bile salt micelles and proteins of human digestive fluid and the soil. Environmental Science and Technology, 34(2), 297-303. https://doi.org/10.1021/es990446j

    2024

    • Oomen, A. G. (2024). Proposal for a qualification system for New Approach Methodologies (NAMs) in the food and feed sector: example of implementation for nanomaterial risk assessment. EFSA Supporting Publications. https://doi.org/10.2903/sp.efsa.2024.EN-9008
    • Oomen, A. G. (2024). Review of New Approach Methodologies for Application in Risk Assessment of Nanoparticles in the Food and Feed Sector: Status and Challenges. EFSA Supporting Publications. https://doi.org/10.2903/sp.efsa.2024.EN-8826

    2021

    • EFSA Scientific Committee (2021). Guidance on technical requirements for regulated food and feed product applications to establish the presence of small particles including nanoparticles. EFSA Journal, 19(8), Article e06769. https://doi.org/10.2903/j.efsa.2021.6769

    2012

    • Dekkers, S., Krystek, P., Peters, R. J. B., Lankveld, D. P. K., Bokkers, B. G. H., Hoeven-Arentzen, P. H. V., Bouwmeester, H., & Oomen, A. G. (2012). Response to Bosch et al. Nanotoxicology, 6(6), 612-613. https://doi.org/10.3109/17435390.2011.595837

    2023

    2022

    • Oomen, A. G., Soeteman-Hernandez, L., Peijnenburg, W., Bleeker, E., Swart, E., Noorlander, C., Haasse, A., Hebel, P., Schwirn, K., Völker, D., & Packroff, R. (2022). Towards Safe and Sustainable Advanced (Nano)materials: A proposal for an Early WArning, pRioritisation and actioN system (EWARN). https://doi.org/10.21945/brochure-advanced-materials
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